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KMID : 0363220100480100893
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Korean Journal of Dermatology
2010 Volume.48 No. 10 p.893 ~ p.897
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Langerhans Cell Histiocytosis That Improved with Oral Isotretinoin Therapy
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Choi Ji-Hyun
Shim Hyun-Chul
Kim Ji-Hye
Kim June-Bum
Shin Mi-Seon
Park Hyang-Joon
Lee Jae-Seung
Joh Ok-Ja
Song Kye-Yong
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Abstract
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Langerhans cell histiocytosis (LCH) is a reactive disease in which abnormal Langerhans cells accumulate in various body sites. We report here on a 51-year-old male patient with LCH that was classified as single-system disease (restricted LCH). The skin lesions were a small, deep ulcer in the right inguinal area and multiple erythematous papules scattered on the lower abdomen, and the patient had these lesions for 1 year. The histopathologic examination revealed a dense histiocytic infiltration in the dermis, and most of the cells showed the characteristics of “LCH” cells. The immunohistochemistry for S-100 protein and CD1a complex all showed positive results. The patient was much improved after surgical excision of the inguinal ulcer and administering oral isotretinoin (20 mg daily) for 8 months, and there was no recurrence. We think retinoid is an effective treatment option for LCH, especially for single system disease.
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KEYWORD
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Isotretinoin, Langerhans cell histiocytosis
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